BBB (Blood-Brain Barrier) is a semi-permeable cell membrane that separates blood from the brain. It is composed of endothelial cells and astrocytes, and exists to protect the brain from circulating pathogens, but also interferes with the penetration of drugs.
The market and limitations of neurological diseases such as Alzheimer's disease, Parkinson's disease, Hunter's syndrome, and brain tumors that are constantly growing due to an aging population
Global drug delivery across blood brain
barrier (BBB) market size by 2026
CAGR 2018 - 2026
The likelihood that the drug will not be delivered to the brain at the right concentration for treatment
of degenerative brain diseases treatment
The lead library of BBB Shuttle Aptamer is prepared by analyzing the sequence of the Aptamer obtained through NGS,
and a core sequence that is commonly repeated is secured through sequence analysis.
BBB-SELEX technology
Create a BBB model using human endothelial cells, and analyze NGS by obtaining an Aptamer that can penetrate the BBB model in the model
Sequencing with Next Generation Sequencer (NGS)
Secure BBB Shuttle Aptamer Lead library and Core sequence
BBB transmission confirmed
Extensibility of application of BBB Shuttle Aptamer-It is possible to develop various BBB Shuttle Aptamer candidates with multiple approaches.
Aptamer-drug conjugate
BBB penetration and effects of CNS drugs
Aptamer-Aptamer conjugate
/ Chimeric aptamer
Bi-functional chimeric aptamer
CNS Imaging
Target-specific CNS imaging